Table 2

Excretion of radioactivity (% dose) in bile, urine, and feces from rats that received i.v. or s.c. 1 μg/kg [3H]hexarelin

Collection PeriodBileUrineFeces2-aCage RinseTotal
h %
i.v.2-b
 0–246.4  ± 0.24
 2–48.43  ± 1.87
 4–63.40  ± 1.05
 6–80.92  ± 0.45
 8–240.60  ± 0.58
 0–2459.75  ± 1.23
 0–7221.95  ± 3.5410.38  ± 1.391.30  ± 0.48
93.38  ± 3.49
s.c.2-c
 0–247.06  ± 1.5
 2–49.47  ± 1.17
 4–61.85  ± 0.25
 6–81.10  ± 0.22
 8–241.32  ± 0.32
 0–2460.82  ± 1.9
 0–7221.96  ± 1.6710.22  ± 0.220.64  ± 0.08
93.76  ± 1.65
  • 2-a Percent dose recovered from the urinary bladder-cannulated rat study.

  • 2-b Values represent the mean ± S.E. of three rats.

  • 2-c Values represent the mean ± S.E. of four rats.