Pharmacokinetic parameters following intravenous (3 mg, A) and oral (10 mg, B) administration of [14C]rizatriptan to humans
| Rizatriptan | Radioactivity | AUC Ratio4-a | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC | CL | Vss | CLr | t1/2 | CLr/CL | AUC | t1/2 | ||||
| ng·hr/ml | ml/min | liters | ml/min | h | ng eq·hr/ml | h | |||||
| A i.v. | |||||||||||
| Mean | 38.1 | 1325 | 154 | 349 | 2.4 | 0.26 | 125.2 | 5.8 | 0.3 | ||
| S.D. | 5.4 | 195 | 28 | 50 | 10.8 | ||||||
| AUC | Cmax | Tmax | CLr | t1/2 | F | AUC | Cmax | Tmax | t1/2 | AUC Ratio4-a | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ng·hr/ml | ng/ml | h | ml/min | h | % | ng eq·hr/ml | ng eq/ml | h | h | ||
| B Oral | |||||||||||
| Mean | 59.8 | 19.8 | 1.4 | 396 | 2.2 | 47 | 333.8 | 59 | 1.8 | 5.6 | 0.17 |
| S.D. | 23.6 | 9.8 | 1.4 | 112 | 43.4 | 8.2 | 1.2 |
↵4-a Calculated as AUC of rizatriptan/AUC of 14C radioactivity.