Selected pharmacokinetic parameters for IA and HI after single i.v. or s.c. doses to Sprague-Dawley rats (n = 36 at each dose level)
| IA | HI | |||||
|---|---|---|---|---|---|---|
| i.v. dosing | ||||||
| Dose (U/kg) | 0.5 | 1.0 | 2.0 | 0.5 | 1.0 | 2.0 |
| t 1/2 (min) | 12 | 12 | 12 | 15 | 10 | 14 |
| AUC0–60min(nM·min) | 48 | 85 | 267 | 35 | 78 | 198 |
| CL (ml/min/kg) | 60 | 67 | 44 | 79 | 74 | 58 |
| s.c. dosing | ||||||
| Dose (U/kg) | 2.0 | 4.0 | 6.0 | 2.0 | 4.0 | 6.0 |
| t 1/2 (min) | 23 | 24 | 22 | 22 | 21 | 23 |
| C max(nM) | 5.2 | 13.8 | 17.4 | 5.0 | 11.7 | 17.7 |
| t max (min) | 15 | 15 | 15 | 15 | 15 | 15 |
| AUC0–240min(nM·min) | 222 | 535 | 815 | 185 | 507 | 913 |
Only three plasma samples were obtained from each rat. Therefore, the pharmacokinetic data in the rat studies are based on mean concentration-time profiles; S.D. values could not be calculated.