Selected pharmacokinetic parameters (mean ± S.D.) for IA and human insulin after a single i.v. or s.c. dose to cross-bred pigs (n = 5)
| IA | HI | P-Value | |
|---|---|---|---|
| i.v. dose (U/kg) | 0.025 | 0.025 | |
| t 1/2(min)3-a | 4.5 (3.9–5.4) | 2.9 (2.0–5.3) | 0.05 |
| AUC0–120min(nM·min) | 3.1 ± 0.9 | 3.6 ± 1.9 | 0.59 |
| CL (ml/min/kg) | 51 ± 15 | 52 ± 25 | 0.98 |
| s.c. dose (U/kg) | 0.125 | 0.125 | |
| t 1/2(min)3-a | 77 (48–125) | 121 (91–160) | 0.09 |
| C max (pM) | 204 ± 76 | 122 ± 34 | 0.13 |
| t max (min) | 73 ± 23 | 99 ± 39 | 0.13 |
| AUC0–300min (nM·min) | 45 ± 27 | 30 ± 3.9 | 0.29 |
↵3-a Harmonic mean with 95% confidence intervals.