Physical properties and human pharmacokinetic data for a set of CYP-3A4 substrates
| Name | Charge | LogD7.4 | Fraction Free in Plasma | CL |
|---|---|---|---|---|
| ml/min/kg | ||||
| Amiodarone | basic | 6.22 | 0.0002 | 1.9 |
| Felodipine | neutral | 4.8 | 0.00401 | 12 |
| Nifedipine | neutral | 2.87 | 0.042 | 7 |
| Haloperidol | basic | 2.71 | 0.087 | 11.8 |
| Bupivacaine | basic | 2.54 | 0.052 | 7.1 |
| Imipramine | basic | 2.52 | 0.11 | 15 |
| Triazolam | neutral | 1.63 | 0.11 | 5.6 |
| Diltiazem | neutral | 2.05 | 0.28 | 12 |
| Alfentanil | basic | 2.11 | 0.086 | 6.7 |
| Quinine | basic | 2.11 | 0.07 | 1.9 |
| Amlodipine | basic | 1.05 | 0.075 | 5.9 |
| Lidocaine | basic | 1.56 | 0.42 | 9.2 |
| Dofetilide | basic | 0.96 | 0.46 | 10.2 |
| Erythromycin | neutral | 0.96 | 0.19 | 9.1 |
| Disopyramide | basic | −0.36 | 0.27 | 1.2 |
Data for human pharmacokinetics as analyzed in Smith, 1997; data taken as in the original publication from Goodman and Gilman, 9th ed.