Effect of PS-ODN administration on regenerating liver weight gain and mitotic index
| Treatment Group | Liver Weight | Mitotic Index | |
|---|---|---|---|
| n | grams | % | |
| Sham PH | Saline (10) | 9.9 ± 0.1 | 0.00 ± 0.00 |
| OL(1)p53 (5) | 10.1 ± 0.2 | nd | |
| p53T (6) | 10.0 ± 0.1 | nd | |
| 24 h PH | Saline (6) | 3.6 ± 0.0 | 0.93 ± 0.20 |
| OL(1)p53 (9) | 3.6 ± 0.1 | 3.60 ± 1.86 | |
| p53T (10) | 4.2 ± 0.1* | 13.30 ± 1.00* | |
| 48 h PH | Saline (3) | 4.1 ± 0.1 | nd |
| OL(1)p53 (3) | 4.2 ± 0.1 | 3.73 ± 0.40 | |
| p53T (7) | 4.9 ± 0.1* | 3.80 ± 0.86 | |
Remnant liver wet weights (in grams) and mitotic indices (in arbitrary units) 24 and 48 h after PH in rats treated with saline or 5 mg/kg/day PS-ODN. Results are expressed as mean ± S.E.
∗ indicates a statistically significant difference ofP < .05 with respect to saline-treated animals in the same group as determined by Tukey's multiple comparison test. n, number of animals in respective groups; nd, not determined.