Table 1

Pharmacokinetic parameters for R-2HMP and major metabolites after s.c. administration to the rat of 10 mg/kg R-2HMP

Tissue/ Compound	AUC_0–240	AUC_0–∞	C_max	T_max	Absorption/Formation		Redistribution		Elimination
					C	γ	t_1/2	A	α	t_1/2	B	β	t_1/2
Brain
R-2HMP	298523	332872	6204 ± 912	15	38351	0.10	7	37503	0.067	10	848	0.0059	117
R-2HMA	47756	51483	704 ± 194	15	16377	0.066	10	16044	0.061	11	333	0.0094	74
R-2HPA	17153	18593	286 ± 36	30	9462	0.046	15	9409	0.043	16	53	0.0069	100
R-2HA	3730	5445	32 ± 13	30	360	0.051	13	336	0.046	15	24	0.0047	149
Liver
R-2HMP	263584	427977	2755 ± 306	30	141341	0.054	13	140234	0.052	13	1107	0.0032	220
R-2HMA	31244	51940	420 ± 89	30	9043	0.043	16	8977	0.039	17	66	0.0020	350
R-2HPA	12303	14343	191 ± 24	15	5070	0.058	12	5030	0.053	13	40	0.0054	129
R-2HA^*	13083	14193	114 ± 19	30	213	0.050	14	213	0.013	54
Plasma
R-2HMP	35338	40886	1125 ± 409	5	1306	3.92	0.2	1128	0.068	10	178	0.0068	101
R-2HMA	15940	17688	194 ± 16	15	268	0.29	2.5	150	0.030	23	118	0.0086	81
R-2HPA	4980	5363	54 ± 11	15	69	0.36	2	20	0.025	28	49	0.010	66
R-2HA^*	1493	2061	13 ± 7	5	12	3.71	0.2	12	0.0069	100

Values were calculated by MOR with a triexponential model, followed by variance-weighted nonlinear regression.
∗, biexponential model was used.
Units: AUC, nanogram · minutes per gram; A, B, C,C_max, nanograms per gram; α, β, γ, min.⁻¹; T_max, t_1/2, min.