Table 1

HPLC profile of radioactivity in plasma

Time1-a(M-1) Acyl Glucuronide(M-2) Carboxylic Acid Metabolite(M-3) Hydroxyl MetaboliteCelecoxib
h % of the radiochromatogram
0.51.1  ± 0.612.1  ± 2.62.43  ± 0.8984.4  ± 3.6
321.0  ± 4.921.2  ± 1.90.86957.6  ± 6.5
1223.3  ± 4.127.0  ± 5.9N.D.49.9  ± 4.5
  • N.D., not detectable.

  • 1-a Values are the mean of data from eight subjects (0.5 and 3 h). Values at 12 h are a mean of data from six subjects due to low levels of radioactivity in plasma in two of the subjects.