Pharmacokinetic parameters of ISBA after i.v. bolus administration (n = 3 or 4 each dose)
| 25 mg/kg | 50 mg/kg | 100 mg/kg | |
|---|---|---|---|
| Parameter | |||
| CL (liters/min/kg) | 0.15 ± 0.01 | 0.13 ± 0.02 | 0.15 ± 0.01 |
| V (liters/kg) | 1.1 ± 0.1 | 1.1 ± 0.01 | 1.2 ± 0.1 |
| t 1/2 (min) | 5.1 ± 0.2 | 5.6 ± 0.4 | 5.6 ± 0.3 |
| Mean Residence Time (min) | 7.4 ± 0.3 | 8.0 ± 0.6 | 8.1 ± 0.5 |
| k el(min−1) | 0.14 ± 0.01 | 0.13 ± 0.01 | 0.12 ± 0.01 |
| Urinary excretion (% dose) | 1-a | 0.49 ± 0.1 | 1-a |
↵1-a not determined.