Table 1

Cumulative urinary excretion of furosemide, natriuresis, and diuresis over a 60-min period, and furosemide natriuretic and diuretic efficiency in rabbits receiving fluid replacement of 13, 121, or 238 ml/h, and 5 mg/kg furosemide as either an i.v. bolus or as an infusion over 60 min

Group	Furosemide Excretion	Natriuresis	Natriuresis Efficiency	Diuresis	Diuresis Efficiency
	mg	mmol	mmol/mg	ml	ml/mg
Bolus 13 ml/l	7.85 ± 0.71	10.2 ± 0.7	1.6 ± 0.2	79.9 ± 3.8	5.1 ± 0.1
Bolus 121 ml/l	6.06 ± 0.79	18.5 ± 1.7^1-a	3.6 ± 0.3^1-a	158.7 ± 14.4^1-a	14 ± 1^1-a
Bolus 238 ml/h	7.30 ± 0.33	27.5 ± 1.7^1-a	3.9 ± 0.3^1-a	219.0 ± 11.7^1-a	30 ± 2^1-a
Infusion 13 ml/l	3.66 ± 0.57^1-a	12.9 ± 0.7	8.9 ± 1.4^1-a	104.3 ± 4.8	33 ± 6^1-a
Infusion 121 ml/l	3.85 ± 0.81^1-c	22.3 ± 1.0^1-b	7.0 ± 1.2	182.7 ± 10.3^1-b	53 ± 11
Infusion 238 ml/h	3.52 ± 0.27^1-d	27.4 ± 3.2^1-b	7.6 ± 0.6^1-d	244.3 ± 11.0^1-b	66 ± 2^1-b ^1-d

Data are presented as mean ± S.E.

↵1-a P < .05 compared with bolus 13 ml/h.
↵1-b P < .05 compared with infusion 13 ml/h.
↵1-c P < .05 compared with bolus 121 ml/h.
↵1-d P < .05 compared with bolus 238 ml/h.