Pharmacokinetic Parameters | Cosalane | Dihydrocosalane | ||||
---|---|---|---|---|---|---|
1.0 | 2.5 | 5.0 | 10.0 | 10.0 | ||
Normal rat | Bile duct-cannulated rat | |||||
mg/kg | mg/kg | |||||
AUC (μg/min/ml) | 11224 ± 1669 | 18821 ± 2716 | 43398 ± 11833 | 86138 ± 19514 | 83999 ± 78356 | 98053 ± 46860 |
α (min−1) | 0.0256 ± 0.0291 | 0.0219 ± 0.006 | 0.0265 ± 0.014 | 0.013 ± 0.006 | 0.0126 ± 0.002 | 0.0084 ± 0.003 |
β (min−1) | 0.0266 ± 0.0438 | 0.0013 ± 0.0001 | 0.002 ± 0.0004 | 0.001 ± 0.0003 | 0.0011 ± 0.0002 | 0.0008 ± 0.0003 |
α half-life (min) | 20 ± 17 | 33 ± 9 | 32 ± 18 | 60 ± 17 | 56 ± 12 | 91 ± 30 |
β half-life (min) | 555 ± 106 | 523 ± 59 | 350 ± 79 | 749 ± 216 | 632 ± 92 | 1016 ± 407 |
Clearance (ml/min/kg) | 0.0204 ± 0.002 | 0.049 ± 0.03 | 0.0263 ± 0.013 | 0.028 ± 0.007 | 0.025 ± 0.002 | 0.074 ± 0.071 |
Volume of distribution (steady state)—(ml/g) | 15.40 ± 2.52 | 20.99 ± 3.36 | 12.57 ± 1.931-150 | 23.10 ± 4.42 | 19.50 ± 1.92 | 24.36 ± 2.54 |
↵1-150 P < .05 compared with other groups except 1.0 mg/kg.