Treatment Group | Testosterone Hydroxylation2-a | |||||||
---|---|---|---|---|---|---|---|---|
2 α (CYP2C11) | 2 β (CYP3A2) | 6 β (CYP3A2) | 7 α (CYP2A1/2) | |||||
− | + | − | + | − | + | − | + | |
nmol/min/mg protein | ||||||||
3 days | ||||||||
Control | 1.371 ± 0.243 | 1.371 ± 0.240 | 0.422 ± 0.146 | 0.422 ± 0.142 | 2.811 ± 0.836 | 2.769 ± 0.854 | 0.053 ± 0.010 | 0.054 ± 0.010 |
MOM | 1.126 ± 0.241 | 1.113 ± 0.248 | 0.421 ± 0.121 | 0.413 ± 0.130 | 2.575 ± 0.648 | 2.521 ± 0.687 | 0.076 ± 0.016 | 0.074 ± 0.012 |
TAO | 0.192 ± 0.0752-150 | 0.198 ± 0.0732-150 | 1.033 ± 0.1472-150 | 3.090 ± 0.4912-150 2-151 | 3.473 ± 0.864 | 8.448 ± 1.6642-150 2-151 | 0.017 ± 0.023 | N.D.2-150 2-151 |
Control | 1.456 ± 0.300 | 1.464 ± 0.350 | 0.424 ± 0.178 | 0.436 ± 0.179 | 3.054 ± 1.232 | 3.042 ± 1.210 | 0.065 ± 0.022 | 0.064 ± 0.021 |
EM | 0.867 ± 0.150 | 0.872 ± 0.139 | 1.367 ± 0.590 | 1.868 ± 0.877 | 7.626 ± 3.260 | 8.781 ± 3.803 | 0.020 ± 0.023 | 0.019 ± 0.021 |
CAM | 0.384 ± 0.2052-150 | 0.385 ± 0.2082-150 | 2.558 ± 0.3262-150 | 3.019 ± 0.3412-150 | 11.083 ± 1.5392-150 | 12.767 ± 1.6782-150 | 0.007 ± 0.0142-150 | N.D.2-150 |
10 days | ||||||||
Control | 1.433 ± 0.454 | 1.406 ± 0.448 | 0.287 ± 0.070 | 0.282 ± 0.072 | 2.060 ± 0.483 | 1.997 ± 1.445 | 0.073 ± 0.024 | 0.071 ± 0.025 |
MOM | 1.362 ± 0.235 | 1.345 ± 0.270 | 0.315 ± 0.095 | 0.313 ± 0.088 | 1.993 ± 0.572 | 1.944 ± 0.533 | 0.072 ± 0.013 | 0.072 ± 0.011 |
Control | 1.263 ± 0.511 | 1.218 ± 0.519 | 0.218 ± 0.099 | 0.222 ± 0.105 | 1.754 ± 0.703 | 1.715 ± 0.738 | 0.045 ± 0.030 | 0.053 ± 0.010 |
EM | 1.184 ± 0.222 | 1.188 ± 0.206 | 0.889 ± 0.1732-150 | 1.160 ± 0.1972-150 | 5.366 ± 1.1292-150 | 6.055 ± 1.1822-150 | 0.044 ± 0.011 | 0.025 ± 0.029 |
CAM | 0.137 ± 0.0952-150 | 0.149 ± 0.1022-150 | 1.949 ± 0.1172-150 | 2.475 ± 0.1182-150 2-151 | 6.738 ± 1.9102-150 | 8.379 ± 2.4142-150 | 0.112 ± 0.074 | 0.104 ± 0.074 |
Treatment Group | Testosterone hydroxylation | Ethoxyresorufin O-deethylation2-b | Aniline p-hydroxylation2-c | |||||
---|---|---|---|---|---|---|---|---|
16 α (CYP2C11) | 16 β (CYP2B1) | (CYPIA) | (CYP2E1) | |||||
− | + | − | + | − | + | − | + | |
nmol/min/mg protein | ||||||||
3 days | ||||||||
Control | 1.884 ± 0.370 | 1.876 ± 0.366 | 0.040 ± 0.023 | 0.039 ± 0.023 | 0.166 ± 0.034 | 0.151 ± 0.025 | 0.634 ± 0.035 | 0.619 ± 0.060 |
MOM | 1.513 ± 0.348 | 1.491 ± 0.363 | 0.052 ± 0.005 | 0.053 ± 0.008 | 0.160 ± 0.036 | 0.150 ± 0.036 | 0.670 ± 0.018 | 0.648 ± 0.030 |
TAO | 0.325 ± 0.1122-150 | 0.297 ± 0.1102-150 | 0.066 ± 0.013 | 0.153 ± 0.0222-150 2-151 | 0.076 ± 0.0218 | 0.168 ± 0.0502-151 | 0.478 ± 0.0562-150 | 0.810 ± 0.0462-150 2-151 |
Control | 2.036 ± 0.418 | 2.041 ± 0.478 | 0.076 ± 0.014 | 0.071 ± 0.017 | 0.139 ± 0.027 | 0.128 ± 0.025 | 0.691 ± 0.111 | 0.668 ± 0.108 |
EM | 1.223 ± 0.234 | 1.239 ± 0.226 | 0.108 ± 0.038 | 0.131 ± 0.056 | 0.145 ± 0.043 | 0.136 ± 0.049 | 0.688 ± 0.238 | 0.699 ± 0.214 |
CAM | 0.880 ± 0.3038 | 0.860 ± 0.2942-150 | 0.224 ± 0.0312-150 | 0.231 ± 0.0302-150 | 0.224 ± 0.050 | 0.193 ± 0.0152-150 | 0.838 ± 0.114 | 0.793 ± 0.044 |
10 days | ||||||||
Control | 1.966 ± 0.700 | 1.933 ± 0.678 | 0.025 ± 0.023 | 0.017 ± 0.024 | 0.194 ± 0.028 | 0.181 ± 0.028 | 0.705 ± 0.084 | 0.674 ± 0.081 |
MOM | 1.838 ± 0.358 | 1.818 ± 0.402 | 0.017 ± 0.023 | N.D. | 0.161 ± 0.030 | 0.150 ± 0.032 | 0.686 ± 0.072 | 0.652 ± 0.071 |
Control | 1.759 ± 0.718 | 1.702 ± 0.736 | 0.046 ± 0.032 | 0.044 ± 0.031 | 0.121 ± 0.042 | 0.113 ± 0.038 | 0.598 ± 0.131 | 0.578 ± 0.111 |
EM | 1.640 ± 0.321 | 1.674 ± 0.318 | 0.083 ± 0.19 | 0.100 ± 0.020 | 0.128 ± 0.030 | 0.115 ± 0.028 | 0.684 ± 0.105 | 0.689 ± 0.085 |
CAM | 0.411 ± 0.155 | 0.434 ± 0.160 | 0.144 ± 0.0192-150 | 0.169 ± 0.0162-150 | 0.196 ± 0.030 | 0.188 ± 0.022 | 0.683 ± 0.045 | 0.703 ± 0.021 |
Each value was expressed as the mean ± S.D. (MOM- or TAO-treated group; n = 5, EM- or CAM-treated group;n = 4).
N.D.; not detectable.
−, without potassium ferricyanide.
+, with potassium ferricyanide.
↵2-150 significantly different from control, P < .01 (Student's t-test).
↵2-151 Significantly different from that without potassium ferricyanide,P < .01 (Student's t-test).
↵2-a The limit of quantitation was 0.04 nmol/min/mg protein.
↵2-b The limit of quantitation was 0.01 nmol/min/mg protein.
↵2-c The limit of quantitation was 0.05 nmol/min/mg protein.