Mb-3 | Mb-5 | Mb-9a | Mb-13 | ||
---|---|---|---|---|---|
Human liver microsomes | K M(μM) | 16.3 ± 4.35-a | 17.8 ± 1.5 | 46.6 ± 5.6 | 11.3 ± 1.2 |
V max (pmol/min/mg protein) | 699 ± 295 | 1410 ± 787 | 2767 ± 1386 | 1588 ± 897 | |
V max/K M (μl/min/mg protein) | 45.3 ± 25.0 | 80.4 ± 45.6 | 61.7 ± 37.6 | 141.3 ± 79.1 | |
Insect cell microsomes | K M(μM) | 15.9 | 21.9 | 34.6 | 17.2 |
Expressed CYP3A45-b | V max(pmol/min/pmolCYP) | 1.44 | 2.93 | 7.28 | 3.76 |
V max/KM(μl/min/pmolCYP) | 0.0906 | 0.1338 | 0.2104 | 0.2186 |