Dose | i.v. Administration | Oral Administration | ||
---|---|---|---|---|
CL | AUC | Cmax | AUC | |
mg/kg | ml/min/kg | μM · h | μM | μM · h |
1 | 23.4 ± 4.9 | 1.29 ± 0.31 | 0.13 ± 0.08 | 0.29 ± 0.15 |
2 | 9.08 ± 1.9 | 6.58 ± 1.21 | 1.47 ± 0.94 | 5.42 ± 3.82 |
5 | 2.55 ± 0.6 | 61.9 ± 15.1 | 6.15 ± 1.72 | 63.6 ± 14.8 |
10 | 1.75 ± 0.4 | 173 ± 43 | 14.9 ± 1.82 | 190 ± 20 |