The Ki values for the inhibition of tolbutamide metabolism by various sulfonamides in human liver microsomes
| Ki | |
|---|---|
| μM | |
| Sulfaphenazole | 0.306 (0.070) |
| Sulfadiazine | 46.2 (8.6) |
| Sulfamethizole | 53.4 (6.6) |
| Sulfisoxazole | 161 (40) |
| Sulfamethoxazole | 283 (45) |
| Sulfapyridine | 427 (145) |
| Sulfadimethoxine | 436 (91) |
| Sulfamonomethoxine | >500 |
Numbers in parentheses represent the S.E.s of the mean values.