Table 1

Metabolism of MPTP in perfused rat liver

Chemicals Infused	Strain of Rat	MPP⁺	MPTP Lactam	MP 2-Pyridone	PTP	MPTP N-Oxide
In the perfusate
MPTP	Jcl:Wistar	0.90	0.74	0.32	0.68	0.91
MPTP+2-OH PM	Jcl:Wistar	1.50	0.07	0.11	0.39	2.70
MPTP	WKA/Sea	0.92	0.03	0.05	0.23	0.94
In the liver
MPTP	Jcl:Wistar	4.32	0.72	0.99	0.67	0.01
MPTP+2-OH PM	Jcl:Wistar	6.66	0.11	ND	0.47	0.01
MPTP	WKA/Sea	3.77	ND	ND	0.23	ND

Rat livers were perfused with 1 mM MPTP in the absence and presence of 5 mM 2-OH PM by a recirculation method as described underMaterials and Methods. After a 90-min perfusion, the metabolites in the perfusate and retained in the liver were determined by HPLC as described under Materials and Methods. The values (μmol/g liver/90 min) represent the average of two experiments.

ND, not detected.