Pharmacokinetic parameters of NFP after id and i.v. administrations in rats preadministered with saline or GJ
| Parameters | id Administration | i.v. Administration | ||||
|---|---|---|---|---|---|---|
| Saline | GJ (single) | GJ (10 days) | Saline | GJ (single) | GJ (10 days) | |
| AUC (μg · h/ml) | 4.85 ± 1.75 | 7.86 ± 2.291-150 | 4.53 ± 1.581-151 | 8.92 ± 1.90 | 9.15 ± 1.13 | 6.73 ± 0.801-150 ,1-151 |
| MRT (h) | 1.03 ± 0.18 | 1.17 ± 0.10 | 0.76 ± 0.07** ,†† | 0.99 ± 0.07 | 0.91 ± 0.06 | 0.77 ± 0.07** ,†† |
| CL/F and CLtot(l/h) | 0.18 ± 0.05 | 0.11 ± 0.031-150 | 0.21 ± 0.05†† | 0.09 ± 0.02 | 0.09 ± 0.01 | 0.13 ± 0.02** ,1-151 |
| Vdss(l) | 0.21 ± 0.07 | 0.14 ± 0.03 | 0.17 ± 0.05 | 0.10 ± 0.02 | 0.09 ± 0.02 | 0.11 ± 0.01 |
| Kel(h−1) | 0.55 ± 0.14 | 0.60 ± 0.11 | 0.83 ± 0.12** ,†† | 0.55 ± 0.09 | 0.65 ± 0.14 | 0.98 ± 0.09** ,†† |
| t1/2(h) | 1.31 ± 0.32 | 1.19 ± 0.27 | 0.85 ± 0.11** ,1-151 | 1.28 ± 0.21 | 1.11 ± 0.26 | 0.71 ± 0.06** ,1-151 |
| Tmax(h) | 0.20 ± 0.05 | 0.27 ± 0.14 | 0.11 ± 0.04†† | |||
| Cmax(μg/ml) | 5.02 ± 1.90 | 5.98 ± 1.73 | 5.70 ± 1.58 | |||
| F (%) | 54.4 | 85.9 | 67.3 | |||
Saline: the rats were administered saline.
GJ (single): the rats were administered GJ 30 min before NFP.
GJ (10 days): the rats were administered GJ for 10 successive days twice a day.
F: the bioavailability was calculated by the following equations: F(saline) = AUC(id, saline)/AUC(i.v. saline), F(GJ-single) = AUC(id, GJ-single)/AUC(i.v. GJ-single), and F(GJ-10 days) = AUC(id, GJ-10 days)/AUC(i.v. GJ-10 days).
↵1-150 P < .05 and ** P < .01; compared with the values in the group administered saline.
↵1-151 P < .05 and††P < .01; compared with the values in the group administered GJ (single).