Concentration of diclofenac, tolbutamide, phenytoin, and celecoxib in the reaction mixture in the presence of 0, 1, 3, and 5% acetonitrile
| Acetonitrile Concentration | Substrate Concentration | |||
|---|---|---|---|---|
| Diclofenac | Tolbutamide | Phenytoin | Celecoxib | |
| % | μM | |||
| 0 | 19.9 ± 0.1 | 992 ± 20 | 77.3 ± 1.41-a | 10.8 ± 0.81-a |
| 1 | 19.5 ± 0.4 | 1016 ± 16 | 77.3 ± 2.11-a | 12.8 ± 0.31-a |
| 3 | 20.0 ± 0.3 | 1012 ± 24 | 73.6 ± 5.11-a | 13.8 ± 0.1 |
| 5 | 20.2 ± 0.2 | 1013 ± 16 | 99.8 ± 0.5 | 15.6 ± 0.6 |
The data are expressed as mean ± S.D. from three determinations.
↵1-a Significantly different from the concentration in the reference solution (P < .05).