Proportions of metabolites in individual samples (0–24 h)
| Bile | Feces | |||||||
|---|---|---|---|---|---|---|---|---|
| 0.7 mg/kg | 50 mg/kg | 0.7 mg/kg | 50 mg/kg | |||||
| Metabolite | M | F | M | F | M | F | M | F |
| M1 | 14.31 | 8.82 | 13.36 | 10.75 | ND | ND | ND | ND |
| M2 | 2.49 | 0.76 | 2.70 | 1.53 | ND | ND | ND | ND |
| M36-a | ND | ND | ND | ND | ||||
| M4 | 5.90 | 3.39 | 5.08 | 4.88 | ND | ND | ND | ND |
| M5 | ND | ND | ND | ND | 4.96 | 0.02 | 3.03 | ND |
| M6 | ND | ND | ND | ND | 18.66 | 9.06 | 15.67 | 9.43 |
| M7 | ND | ND | ND | ND | 5.42 | 1.06 | 4.27 | 1.88 |
| M8 | ND | ND | ND | ND | 0.92 | 0.09 | 1.38 | 0.44 |
| M9 | ND | ND | ND | ND | 1.94 | 1.39 | 0.87 | 0.48 |
| M10 | ||||||||
| Levormeloxifene | ND | ND | ND | ND | 7.26 | 7.76 | 9.93 | 3.92 |
Results expressed as percent dose.
ND, below limit of detection.
↵6-a Metabolite M3 was isolated from bile samples after treatment with β-glucuronidase and was the aglucan of M4.