Dose, mg/kg | Kp | Kpu | ||||
---|---|---|---|---|---|---|
1.2 | 6 | 30 | 1.2 | 6 | 30 | |
Lung | 7.14 | 5.10 | 4.22 | 132 | 82.4 | 50.7 |
Heart | 5.88 | 4.63 | 3.82 | 108 | 74.8 | 45.9 |
Kidney | 7.69 | 10.4 | 6.70 | 142 | 168 | 80.5 |
Bone | 2.27 | 3.03 | 1.63 | 41.9 | 48.9 | 19.6 |
Muscle | 0.98 | 1.18 | 1.08 | 18.1 | 19.1 | 13.0 |
Spleen | 7.38 | 6.97 | 5.47 | 136 | 113 | 65.7 |
Liver | 11.8 | 11.0 | 8.59 | 218 | 178 | 103 |
Gut | 5.15 | 5.23 | 3.87 | 95.0 | 84.4 | 46.5 |
Skin | 4.17 | 2.45 | 1.70 | 76.9 | 39.5 | 20.4 |
Fat | 6.74 | 6.27 | 7.48 | 124 | 101 | 89.8 |
Thymus | 3.62 | 5.23 | 3.39 | 66.7 | 84.5 | 40.7 |
Brain | N.D.2-b | 0.24 | 0.80 | N.D.2-b | 3.90 | 9.55 |
V ss(l/kg)2-c | 2.40 | 2.24 | 1.83 | 44.2 | 36.1 | 22.0 |
The values were determined for each tissue using an AUC method2-a(Gallo et al., 1987). The values of Vss were calculated using those ratios and the respective organ volumes (Kawai et al., 1994).
↵2-a Time- and subject-averaged values obtained from pooled concentration-time data in each dose group (n = 15; three animals per time point).
↵2-b N.D., not determined (because most brain measurements were below the limit of quantification).
↵2-c Calculated from the sum ofVTKp orVTKpu for all organs measured, including blood, where VT is organ mass.