Pharmacokinetic parameters for methylphenidate (MPH), ethylphenidate (EPH), ritalinic acid (RA), and ethanol (EtOH)
| AUC | Apparent Half-Life | tmax | Cmax | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MPH | EPH | RA | EtOH | MPH | EPH | RA | EtOH | MPH | EPH | RA | EtOH | MPH | EPH | RA | EtOH | |
| ng/ml/h | mg/dl/h | h | h | ng/ml | mg/dl | |||||||||||
| NO | 33 | 0.5 | 917 | 75 | 2.9 | 1.3 | 3.0 | 0.8 | 1.0 | 1.5 | 1.0 | 1.5 | 8.4 | 0.17 | 260 | 31.1 |
| JB | 46 | 1.6 | 1047 | 99 | 3.9 | 2.1 | 4.1 | 1.2 | 3.0 | 2.1 | 1.5 | 2.1 | 10.0 | 0.48 | 260 | 35.1 |
| RH | 49 | 0.9 | 941 | 63 | 5.3 | 1.3 | 8.4 | 1.1 | 3.0 | 2.0 | 4.0 | 1.5 | 13.5 | 0.35 | 242 | 31.1 |
| JW | 37 | 0.2 | 1045 | 98 | 2.2 | 1.3 | 2.8 | 1.5 | 1.0 | 1.0 | 1.5 | 1.5 | 12.4 | 0.12 | 326 | 46.0 |
| KP | 68 | 1.8 | 1430 | 216 | 2.1 | 1.3 | 3.0 | 2.4 | 1.0 | 1.0 | 1.5 | 2.0 | 27.3 | 0.81 | 394 | 70.7 |
| LB | 57 | 2.2 | 1086 | 50 | 5.1 | 1.6 | 4.8 | 2.5 | 4.0 | 3.0 | 4.0 | 2.0 | 15.9 | 0.65 | 304 | 25.5 |
| Mean | 48 | 1.2 | 1078 | 100 | 3.6 | 1.5 | 4.3 | 1.6 | 2.2 | 1.8 | 2.3 | 1.8 | 14.6 | 0.43 | 298 | 39.9 |
| S.D. | 12 | 0.7 | 169 | 55 | 1.4 | 0.3 | 2.1 | 0.7 | 1.3 | 0.8 | 1.4 | 0.3 | 6.8 | 0.27 | 57 | 16.6 |
AUC, terminal elimination phase half-lives, time to maximum concentration (tmax), and maximum concentration (Cmax) for MPH, EPH, RA, and EtOH for six healthy subjects administered a single oral dose of MPH followed 30 min later by 0.6 g/kg EtOH over 15 min.