Table 1

Urinary excretion (0–24 h) of the mercapturic acid adduct (M4) after single and multiple daily doses of L-745,870 (10 mg p.o.) to human volunteers

SubjectDose
Day 1Day 10
mg % mg %
AN0011.7190.31-a 41-a
AN0030.9102.41-b 261-b
AN0041.3153.034
AN0061.7193.943
AN0071.4164.651
AN0080.9101.921
AN0091.7193.437
AN0101.7191.820
AN0122.0223.336
Mean ± S.D.1.5 ± 0.417 ± 4%3.0 ± 1.01-c 34 ± 11%1-c

  • ↵1-a Subject AN001 received only seven doses. The result was obtained from specimens collected between 2 and 3 days after the last dose.

  • ↵1-b 0 to 12 h excretion.

  • ↵1-c The mean value does not include subject AN001.