Pharmacokinetic parameters for rhNGF after single or multiple administration (2 mg/kg) in monkeys
| Parameter (n = 4) | Dose 1 | Dose 12 |
|---|---|---|
| Cmax(μg/ml) | 1.3 ± 0.12 | 4.1 ± 1.22-a |
| Tmax (h) | 2.5 ± 2.7 | 3.3 ± 0.96 |
| CL/F (ml/kg/h) | 140 ± 15 | 63 ± 24 |
| Vz/F (ml/kg) | 827 ± 283 | 436 ± 174 |
| MRT (h) | 8.3 ± 1.0 | 7.2 ± 1.5 |
| t1/2(h) | 4.1 ± 1.0 | 4.8 ± 0.4 |
| AUCinf(μg · h/ml) | 14.5 ± 1.6 | 37.6 ± 20.82-a |
Pharmacokinetic parameters were determined from NGF plasma concentration-time ELISA profiles as described in Materials and Methods. Results are the mean ± S.D. of four animals per dose.
↵2-a The plasma concentrations for one animal were much greater than the other three animals after dose 12. Estimates of Cmax and AUCinf, assuming this animal to be an outlier, are: Cmax = 3.5 ± 0.3 and AUCinf = 27.4 ± 4.4. Tmax, time of maximum rhNGF plasma concentration; CL/F, plasma clearance; MRT, mean residence time in the body; t1/2, terminal half-life; AUCinf, area under the curve extrapolated from time 0 to infinity.