Inhibition of morphine glucuronidation by FNZ in dog and human liver microsomes
| Species | Morphine Glucuronidation Rate | Morphine Glucuronidation Rate with 50 μM FNZ | Percentage of Inhibition |
|---|---|---|---|
| nmol/min/mg of protein | |||
| Dog 123 | 38 ± 1 | 20 | 48 |
| Human F | 5.5 ± 0.3 | 3.7 ± 0.3 | 32 |
FNZ (50 μM) inhibited morphine glucuronidation in dog and human liver microsomes. Assays are described in Materials and Methods. Values represent an average of two incubations or mean ± S.D. of three incubations.