Mean concentrations of 14C-radioactivity in representative tissues from rats administered a single oral dose of 10 mg/kg oseltamivir
| Tissue | Concentration | ||
|---|---|---|---|
| 1 h | 6 h | 24 h | |
| μg Eq./g | |||
| Brain | 0.033 ± 0.009 | 0.016 ± 0.005 | 0.001 ± 0.002 |
| Kidneys | 11.951 ± 2.273 | 2.555 ± 1.051 | 0.228 ± 0.036 |
| Liver | 25.826 ± 4.959 | 5.385 ± 2.144 | 0.447 ± 0.073 |
| Lung | 1.945 ± 0.538 | 0.411 ± 0.152 | 0.032 ± 0.002 |
| Skeletal muscle | 0.412 ± 0.133 | 0.047 ± 0.015 | 0.007 ± 0.005 |
| Small intestine | 38.014 ± 8.161 | 2.376 ± 1.995 | 0.049 ± 0.054 |
| Large intestine | 1.238 ± 0.419 | 13.311 ± 5.552 | 0.399 ± 0.184 |
| Plasma | 1.059 ± 0.209 | 0.200 ± 0.041 | 0.000 ± 0.000 |
| Stomach | 14.321 ± 5.375 | 1.040 ± 1.072 | 0.047 ± 0.031 |
| Stomach contents | 274.859 ± 42.278 | 6.826 ± 10.847 | 0.070 ± 0.140 |
| Small intestine contents | 287.669 ± 70.844 | 12.457 ± 5.502 | 0.384 ± 0.403 |
| Large intestine contents | 1.008 ± 0.354 | 148.337 ± 58.719 | 6.282 ± 2.204 |