Dose | Rosiglitazone | Total Radioactivity | |||||||
---|---|---|---|---|---|---|---|---|---|
Tmax1-a | Cmax | AUC0-inf | t1/2 | CL | VSS | F | Tmax1-a | Cmax | |
h | ng/ml | ng · h/ml | h | l/h | l | % | h | ng eq./ml | |
Oral dose of [14C]rosiglitazone (solution), 8-mg | 0.5 | 564 | 2,900 | 4.65 | 95 | 5.0 | 885 | ||
(0.5–1.0) | (19) | (548) | (1.51) | (88–101) | (4.0–6.0) | (173) | |||
Oral dose of rosiglitazone (tablet), 8-mg | 0.75 | 603 | 2,930 | 4.06 | 99 | ||||
(0.75–1.0) | (332) | (473) | (1.23) | (86–106) | |||||
Dose of [14C]rosiglitazone, 2-mg i.v. | 1.0 | 146 | 744 | 4.16 | 2.78 | 15.1 | 6.0 | 226 | |
(0.75–1.0) | (40) | (142) | (1.64) | (0.63) | (4.1) | (6.0–6.7) | (43) |
↵1-a Values expressed as median (range).