FBM-dosed Sprague-Dawley rats
| FBM-Dosed Sprague-Dawley Rat | CPPA | MCF-Glucuronide | Nac-OH1-a | Nac-Acid | CPPA/Mercapturates | CPPA + Mercapturates/ MCF-Glucuronide |
|---|---|---|---|---|---|---|
| % FBM | ||||||
| 1 | 6.9 ± 0.1 | 7.8 ± 0.0 | 1.1 ± 0.0 | 0.5 ± 0.0 | 6.1 | 1.1 |
| 2 | 8.0 ± 1.9 | 9.2 ± 0.8 | 1.9 ± 0.8 | 1.1 ± 0.4 | 4.3 | 1.2 |
| 3 | 11.3 ± 1.2 | 9.8 ± 0.1 | 0.6 ± 0.0 | 0.3 ± 0.0 | 18.2 | 1.2 |
| 4 | 14.0 ± 0.0 | 11.3 ± 0.1 | 2.2 ± 0.1 | 1.2 ± 0.0 | 6.0 | 1.5 |
| 5 | 12.5 ± 0.9 | 9.3 ± 0.4 | 0.7 ± 0.0 | 0.3 ± 0.0 | 17.6 | 1.5 |
| 6 | 12.5 ± 3.9 | 8.2 ± 0.5 | 1.6 ± 0.0 | 0.7 ± 0.0 | 7.9 | 1.8 |
| Average | 10.9 ± 2.6 | 9.3 ± 1.1 | 1.4 ± 0.6 | 1.9 ± 0.9 | 10.0 ± 5.7 | 1.4 ± 0.2 |
All metabolites are reported as a percentage of excreted felbamate. Mercapturates = Nac-OH + Nac acid combined.
↵1-a Nac-OH,N-acetyl-S-(2-phenylpropan-3-ol)-lcysteine; Nac-acid, (2-phenylpropanoic)-l-cysteine.