FBM-dosed Gunn rats
| FBM-Dosed Gunn Rat | CPPA | MCF-Glucuronide | Nac-OH4-a | Nac-Acid | CPPA/Mercapsurate | CPPA + Mercapsurate/MCF-Glucuronide |
|---|---|---|---|---|---|---|
| 1 | 28.3 ± 1.3 | 15.8 ± 0.1 | 7.5 ± 0.0 | >0.2 | 2.3 | 2.3 |
| 2 | 11.4 ± 0.7 | 44.5 ± 1.6 | 5.6 ± 0.1 | >0.2 | 0.4 | 0.4 |
| 3 | 10.0 ± 0.9 | 26.4 ± 2.7 | 5.4 ± 0.1 | >0.2 | 1.9 | 0.6 |
| Average | 16.6 ± 8.3 | 28.9 ± 11.8 | 6.2 ± 0.9 | 2.6 ± 0.9 | 1.1 ± 0.8 |
All metabolites are reported as a percentage of excreted felbamate. Mercapturates = Nac-OH + Nac acid combined.
↵4-a Nac-OH,N-acetyl-S-(2-phenylpropan-3-ol)-l-cysteine; Nac-acid, N-acetyl-S-(2-phenylpropanoic acid)-l-cysteine.