MCF-dosed Gunn rats
| MCF-Dosed Gunn Rat | CPPA | MCF-Glucuronide | Nac-OH5-a | Nac-Acid | CPPA/ Mercapsurate | CPPA + Mercapsurate/ MCF-Glucuronide |
|---|---|---|---|---|---|---|
| 1 | 176 ± 22 | 939 ± 182 | 26.8 ± 1.1 | 12.5 ± 0.6 | 4.5 | 0.2 |
| 2 | 596 ± 9 | 3975 ± 1493 | 89.0 ± 1.5 | 39.3 ± 0.5 | 4.7 | 0.2 |
| 3 | 721 ± 16 | 4458 ± 114 | 115 ± 4 | 48.6 ± 1.6 | 4.4 | 0.2 |
| Average | 498 ± 233 | 3124 ± 1557 | 76.9 ± 37 | 33.5 ± 15.3 | 4.5 ± 0.1 | 0.2 ± 0.0 |
All metabolites are reported as a percentage of excreted felbamate. Mercapturates = Nac-OH + Nac acid combined.
↵5-a Nac-OH,N-acetyl-S-(2-phenylpropan-3-ol)-l-cysteine; Nac-acid, N-acetyl-S-(2-phenylpropanoic acid)-l-cysteine.