Effect of mibefradil, ketoconazole, and PSC833 on P-gp determined using digoxin transport in Caco-2 cells, and CYP3A-mediated nifedipine oxidase activity in human liver microsomes
IC50
Ki
P-gp
CYP3A
CYP3A
μM
μM
Mibefradil
1.6
0.80
0.6
Ketoconazole
1.4
0.15
0.05
PSC 833
0.11
10
16
Each experiment was performed on at least two different experimental days.