Pharmacokinetic parameters of the unbound and total VPA in four newborn lambs
| Unbound VPA | Total VPA | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CLutb | t1/2uβ | MRTu | VDuss | CLtb | t1/2β | MRT | fp | Vdss | Vdss′5-a | |
| NL42415-b | 0.78 | 12.9 | 18.1 | 0.84 | 0.27 | 20.5 | 23.6 | 0.35 | 0.38 | 0.29 |
| NL4124 | 1.00 | 9.7 | 12.8 | 0.77 | 0.33 | 16.5 | 17.5 | 0.33 | 0.35 | 0.26 |
| NL0123z | 0.37 | 12.2 | 18.0 | 0.40 | 0.16 | 20.6 | 25.5 | 0.44 | 0.25 | 0.17 |
| NL2241(1) | 0.50 | 13.4 | 17.4 | 0.53 | 0.25 | 16.8 | 21.7 | 0.49 | 0.32 | 0.26 |
| Mean ± S.D. | 0.66 ± 0.285-c | 12.1 ± 1.65-d | 16.6 ± 2.55-d | 0.63 ± 0.215-e | 0.25 ± 0.075-c | 18.6 ± 2.35-d | 22.1 ± 3.45-d | 0.40 ± 0.08 | 0.33 ± 0.065-e | 0.25 ± 0.055-e |
↵5-a Vdss′: corrected steady-state volume of distribution of the total drug in liters per kilogram; fp: area weighted unbound fraction of the drug. Superscript ‘u’ in the above symbols refers to the same pharmacokinetic parameters for the unbound drug.
↵5-b This lamb was offspring of E4241.
↵5-c Significantly lower than the corresponding maternal and fetal values in Table 4 (P < .05).
↵5-d Significantly longer than the corresponding maternal and fetal values in Table 4 (P < .05).
↵5-e Significantly lower than the corresponding fetal values in Table 4 (P < .005).