Drug or Metabolite | Percentage of Administered Dose in Maternal Urine (n = 5) | Percentage of Administered Dose in Newborn Urine (n = 4) |
---|---|---|
Unchanged VPA | 19.30 ± 5.81 | 10.98 ± 5.872-a |
VPA-Glucuronide | 76.96 ± 7.81 | 28.30 ± 11.982-a |
(E)-2-ene VPA | 0.02 ± 0.01 | 0.11 ± 0.042-b |
(E)-3-ene VPA | 0.01 ± 0.03 | 0.01 ± 0.002-b |
3-keto VPA | 1.56 ± 0.78 | 11.60 ± 3.482-b |
4-ene VPA | 0.03 ± 0.02 | 0.01 ± 0.01 |
4-keto VPA | 0.42 ± 0.12 | 0.07 ± 0.032-a |
3-OH VPA | 0.20 ± 0.04 | 0.66 ± 0.102-b |
4-OH VPA | 2.31 ± 1.26 | 6.13 ± 3.192-b |
5-OH VPA | 0.76 ± 0.55 | 2.15 ± 0.552-b |
2-PSA | 0.09 ± 0.03 | 0.08 ± 0.09 |
2-PGA | 0.85 ± 0.44 | 0.74 ± 0.50 |
Total | 102.52 ± 7.00 | 60.85 ± 11.72 |