Pharmacokinetic parameters of renal elimination of VPA in maternal, fetal, and newborn sheep
| Parameter | Maternal (n = 5) | Fetal (n = 4) | Newborn (n = 3) |
|---|---|---|---|
| ml/min/kg | |||
| Renal clearance of total VPA | 0.26 ± 0.08 | 0.01 ± 0.003-a | 0.03 ± 0.023-a |
| Renal clearance of unbound VPA (CLu r) | 0.94 ± 0.40 | 0.02 ± 0.013-a | 0.08 ± 0.063-a |
↵3-a Significantly lower than the corresponding maternal renal clearance (P < .05).