Table 1

VPA pharmacokinetic parameters in 10 d, 1 M, 2 M, and adult sheep

AgeTotal VPAUnbound VPAfp
Cltbt1/2βMRTVdssVdss′Clutbtu1/2βMRTuVduss
ml/min/kg h h l/kg l/kg ml/min/kg h h l/kg
10 d (n = 8)0.55  + 0.387.0 ± 3.410.0 ± 4.91-a 0.22 ± 0.080.14 ± 0.062.65 ± 1.161-a 10.6 ± 8.51-b 6.7 ± 2.81-b 0.79 ± 0.321-b 0.21 ± 0.121-b
1 M (n = 4)0.50  + 0.275.2 ± 1.17.2 ± 1.90.19 ± 0.070.14 ± 0.075.11 ± 2.492.5 ± 1.23.2 ± 1.61.48 ± 0.320.10 ± 0.01
2 M (n = 5)1.40  + 0.581-a 2.6 ± 0.73.5 ± 1.10.30 ± 0.060.16 ± 0.0312.84 ± 3.881-a 1.5 ± 0.51.8 ± 0.61.54 ± 0.390.11 ± 0.03
Adult (n = 5)0.70  + 0.314.2 ± 2.05.7 ± 2.80.24 ± 0.030.13 ± 0.027.73 ± 2.641.7 ± 0.72.1 ± 0.91.47 ± 0.510.09 ± 0.02

  • ↵1-a  Statistically different from adult age group (P < .05).

  • ↵1-b  Statistically different from 1 M, 2 M, and adult age groups (P < .05).