Table 3

Recovery of VPA and its metabolites as a percentage of the total dose in 10 d, 2 M, and adult sheep after administration of a 10 mg/kg i.v. bolus

Drug or Metabolite% of Administered Dose Recovered in Urine
10 d (n = 4)2 M (n = 4)Adult (n = 5)
VPA5.6  ± 3.13-a 3.0  ± 1.33-a 12.2  ± 2.2
VPA-glucuronide29.2  ± 16.03-b 74.6  ± 3.273.8  ± 5.3
3-keto12.6  ± 9.813.2  ± 5.811.3  ± 6.5
4-OH VPA0.6  ± 0.43-b 1.6  ± 0.32.0  ± 0.6
Other3-c 1.1  ± 0.61.4  ± 0.22.2  ± 0.9
% of Dose Recovered49.1  ± 25.693.7  ± 9.63101.5  ± 8.5

  • ↵3-a  Statistically different from adult age group (P < .05).

  • ↵3-b  Statistically different from 2 M and adult age groups (P < .05).

  • ↵3-c  Includes 3-OH, 5-OH, (E)-2-ene, (E)-3-ene, 4-ene, 4-keto VPA, 2-PSA, and 2-PGA.