Table 1

Comparative noncompartmental pharmacokinetic parameters for rats administered a single i.v. bolus dose, a single oral dose, or a single dermal application of dapsone

Route of Administration	Dapsone Dose	AUC_{0–24 h}	AUC_0–∞	C_max	t_max	t_1/2	% Bioavailability
		ng · h/ml	ng · h/ml	ng/ml	h	h
Intravenous^1-a	12 mg/kg	37,741	38,323	10,474		4.27
Oral	12 mg/kg	29,296	29,947	4,890	1	4.38	78.1
Dermal (1% in 10% DGME)	3 mg	25.9	62.2	1.62	6	28.4	0.16
	(12 mg/kg)
Dermal (1% in 25% DGME)	3 mg	77.7	94.9	5.56	6	8.42	0.25
	(12 mg/kg)
Dermal (5% in 25% DGME)	15 mg	260.8	1,507	12.8	8	77.8	0.79
	(60 mg/kg)

↵1-a CL = 313 ml/h/kg andV_ss = 1582 ml/kg for single i.v. bolus dose.