Table 4

Kinetic characteristics of lidocaine metabolism by cDNA-expressed (recombinant) human CYP3A4 and CYP1A2

	MEGX		3-OH-lidocaine
	K_m	V_max^4-a	CL_int^4-b	K_m	V_max^4-a	CL_int^4-c
	μM			μM
CYP3A4	1032	254	0.25	1435	0.3	0.21
CYP1A2	810	190	0.23	818	2.7	3.3

Kinetic parameters (K_m and V_max) were estimated by nonlinear regression analysis using the Michaelis-Menten equation. The CL_int was calculated by dividingV_max by K_m.

↵4-a In picomoles per minute per picomoles of P450.
↵4-b In microliters per minute per picomoles of P450 (not adjusted for relative abundance).
↵4-c In nanoliters per minute per picomoles of P450 (not adjusted for relative abundance).