The inhibitory effect of linezolid on specific CYP enzyme activities in cDNA-expressed CYP microsomes
| CYP Enzyme | % Control of P-450 Marker Substrate Metabolism | |
|---|---|---|
| Linezolid (10 μM) | Linezolid (100 μM) | |
| CYP1A2 | 100.4 ± 3.32-a | 101.7 ± 6.62-a |
| CYP2C9 | 102.1 ± 1.6 | 95.2 ± 1.0 |
| CYP2C19 | 106.6 ± 17.5 | 114.5 ± 11.2 |
| CYP2D6 | 94.7 ± 7.1 | 92.4 ± 4.3 |
| CYP2E1 | 91.5 ± 27.2 | 106.2 ± 25.3 |
| CYP3A4 | 92.6 ± 4.5 | 96.0 ± 5.4 |
Values are the mean ± S.D. of triplicate determinations. Incubation conditions and concentrations of CYP marker substrates are as described under Experimental Procedures.
↵2-a Mean ± S.D.