The induction of mEH mRNA by agents able to preferentially induce detoxifying enzymes
| Inducing Agent | mEH mRNA (% Zero-Time Value) | |||||
|---|---|---|---|---|---|---|
| 0 | 6 h | 12 h | 12 h and actinoD | 18 h | 24 h | |
| None | 100 ± 23 | 55 ± 11 | ||||
| 1,7-P (solution) | 100 ± 14 | 155 ± 18 | 482 ± 1063-a | 287 ± 463-a | ||
| 1,7-P (suspension) | 100 ± 23 | 471 ± 1333-a | 104 ± 30 | 459 ± 1413-a | ||
| Oltipraz (75 mg/kg) | 100 ± 14 | 112 ± 16 | 392 ± 473-a | 421 ± 1263-a | 247 ± 1343-a | |
| Oltipraz (100 mg/kg) | 100 ± 23 | 429 ± 1253-a | 136 ± 22 | |||
| BHA | 100 ± 23 | 87 ± 13 | 67 ± 1 | 58 ± 4 | 98 ± 12 | |
| BHQ | 100 ± 19 | 63 ± 11 | 113 ± 14 | 58 ± 17 | 75 ± 4 | 82 ± 4 |
Values are expressed as mean ± S.E., with n = 3–4.
1,7-P, 1,7-phenanthroline; actinoD, actinomycin D, 2 mg/ml given 1 h before inducer.
↵3-a Significantly different (P < .05) from controls.