Table 6

The induction of UGT1A1 mRNA by agents able to preferentially induce detoxifying enzymes

Inducing AgentUGT1A1 mRNA (% Zero-Time Value)
06 h12 h12 h and actinoD18 h24 h
None100  ± 12144  ± 33
1,7-P (solution)100  ± 14105  ± 10130  ± 24169  ± 266-a
1,7-P (suspension)100  ± 12214  ± 96-a 6-b 163  ± 236-a 6-c 203  ± 336-a
Oltipraz (75 mg/kg)100  ± 1495  ± 11144  ± 11105  ± 27143  ± 18
Oltipraz (100 mg/kg)100  ± 12208  ± 286-a 165  ± 296-a 6-c
BHQ100  ± 12129  ± 16
Phenobarbital100  ± 9125  ± 13

Values are expressed as mean ± S.E., with n = 3–4.

  • 1,7-P, 1,7-phenanthroline; actinoD, actinomycin D, 2 mg/ml given 1 h before inducer.

  • ↵6-a  Significantly different (P < .05) from controls.

  • ↵6-b  Significantly different (P < .05) from solution formulation.

  • ↵6-c  Significantly different (P < .05) from 75 mg/kg.