KI and kinact estimated in vitro using human liver microsomes
| KI | kinact | |
|---|---|---|
| μM | min−1 | |
| MA | 0.77 ± 0.04 | 0.027 ± 0.001 |
| CLY | 5.49 ± 0.48 | 0.072 ± 0.004 |
| FLU | 5.26 ± 1.28 | 0.017 ± 0.002 |
All values are ±S.E. Parameters were estimated by fitting the data shown in Figs. 2, a to c, to eqs. 9 and 10.
CLY, clarithromycin; FLU, fluoxetine.