Table 2

Relationship between CLtotal and CLhepatic after intravenous administration of 0.3 mg/kg of 125I-pamiteplase or125I-rwt-PA to rats

CLtotal2-aCLhepatic2-bCLhepatic/CLtotal
ml/min/kg ml/min/kg
Pamiteplase7.445.600.75
rwt-PA33.5428.850.86
  • 2-a  CLtotal quoted from Table 1.

  • 2-b  CLhepatic calculated from integration plot using mean of three rats.