Table 2

Summary of correlation data between ezlopitant metabolism and cytochrome P450 isoform specific marker substrate activities^2-a

	CYP1A2	CYP2C9	CYP2C19	CYP2D6	CYP3A4
	Correlation Coefficient (r²)
[S] = 0.3 μM
Ezlopitant consumption	0.329	0.020	0.200	0.243	0.389
CJ-12,458 formation	0.295	0.000	0.040	0.315	0.598^2-b
CJ-12,764 formation	0.453	0.002	0.065	0.372	0.434
[S] = 10 μM
Ezlopitant consumption	0.347	0.005	0.044	0.280	0.637^2-b
CJ-12,458 formation	0.346	0.002	0.048	0.249	0.627^2-b
CJ-12,764 formation	0.442	0.002	0.069	0.217	0.485
[S] = 100 μM
Ezlopitant consumption	0.256	0.001	0.137	0.063	0.466
CJ-12,458 formation	0.326	0.004	0.016	0.174	0.752^2-b
CJ-12,764 formation	0.359	0.003	0.040	0.114	0.657^2-b