Parameters | EMs (n = 8) | PMs (n = 5) | ||
---|---|---|---|---|
With Diltiazem (A) | With Placebo (B) | With Diltiazem (C) | With Placebo (D) | |
Diazepam | ||||
AUC0–144 (ng · h/ml) | 1620 ± 1411-a 1-c | 1302 ± 92 | 2333 ± 2751-e | 1858 ± 2371-f |
CL/F (ml/min/kg) | 0.146 ± 0.0151-a 1-c | 0.184 ± 0.023 | 0.093 ± 0.0161-e | 0.119 ± 0.020 |
t 1/2 (h) | 65.0 ± 20.51-b 1-c | 45.6 ± 12.9 | 103.8 ± 40.21-e | 77.0 ± 28.61-f |
N-Desmethyldiazepam | ||||
AUC0–144(ng · h/ml) | 1277 ± 140 | 1259 ± 84 | 1159 ± 111 | 1144 ± 69 |
AUC0–408(ng · h/ml) | 2714 ± 1561-d | 2275 ± 263 | 3794 ± 2451-e | 3203 ± 2741-f |