Table 1

Mean pharmacokinetic parameters of diazepam and N-desmethyldiazepam in EM and PM groups with diltiazem or placebo

ParametersEMs (n = 8)PMs (n = 5)
With Diltiazem (A)With Placebo (B)With Diltiazem (C)With Placebo (D)
Diazepam
 AUC0–144 (ng · h/ml)1620  ± 1411-a 1-c 1302  ± 922333  ± 2751-e 1858  ± 2371-f
 CL/F (ml/min/kg)0.146  ± 0.0151-a 1-c 0.184  ± 0.0230.093  ± 0.0161-e 0.119  ± 0.020
 t 1/2 (h)65.0  ± 20.51-b 1-c 45.6  ± 12.9103.8  ± 40.21-e 77.0  ± 28.61-f
N-Desmethyldiazepam
 AUC0–144(ng · h/ml)1277  ± 1401259  ± 841159  ± 1111144  ± 69
 AUC0–408(ng · h/ml)2714  ± 1561-d 2275  ± 2633794  ± 2451-e 3203  ± 2741-f

Values represent the mean ± S.E.

  • ↵1-a  p < 0.05 in A versus B.

  • ↵1-b  p < 0.01 in A versus B.

  • ↵1-c  p < 0.05 in A versus C.

  • ↵1-d  p < 0.01 in A versus C.

  • ↵1-e  p < 0.05 in C versus D.

  • ↵1-f  p < 0.05 in B versus D.