Inhibitor | Product Formation | |||
---|---|---|---|---|
S(−)-Cibenzoline | R(+)-Cibenzoline | |||
M1 | M3 | M1 | M3 | |
% control | ||||
Quinidine (10 μM) | 41 | 56 | 54 | 49 |
Ketoconazole (2.5 μM) | 26 | 18 | 14 | 10 |
Cibenzoline enantiomers at 5 μM substrate concentration were incubated with male rat liver microsomes at 37°C for 10 min in the presence of NADPH generating system. Results represent mean of duplicate determinations.