Table 2

Estimation of CL_{int, in vivo} from in vivo pharmacokinetic data for the model compounds in rats, dogs, and humans

Compounds	Species	CL_oral or CL_tot	F_a	f_p	R_B	CL_{int, in vivo}		E_H	Reference
Compounds	Species	CL_oral or CL_tot	F_a	f_p	R_B	Well Stirred	Parallel-Tube	E_H	Reference	Dispersion
		ml/min/kg body weight				ml/min/kg body weight
FK1052	Rat	875	0.95	0.03	1.21	27708.33	5785.60	7952.74	0.93	In house data
	Dog	62.7		0.017	0.82	3503.82	1802.28	2114.04	0.70
	Human	26.4		0.016	0.78	1567.50	945.95	1071.18	0.61
FK480	Rat	81.1	0.70	0.01	0.626	5677.00	3358.32	3824.30	0.62	In house data
	Dog	6.6		0.006	0.6	770.00	687.51	709.16	0.20
	Human	2.4		0.005	0.6	336.00	315.14	320.79	0.12
Zolpidem	Rat	106	0.89	0.13	0.89	725.69	405.00	466.88	0.66	Ishibashi et al. (1993a,b)
	Human	7.1		0.04	0.66	157.98	129.84	137.31	0.32	Kudo et al. (1990)
Omeprazole	Rat	710	1.00	0.125	0.78	5680.00	985.69	1393.01	0.94	Watanabe et al. (1994)
	Dog	6.3^2-a		0.097	0.60	98.38	79.36	84.03	0.34	Regårdh et al. (1985)
	Human	22.2		0.042	0.62	528.57	306.86	350.73	0.63	Andersson et al. (1990)
Nicardipine	Rat	1212	1.00	0.084	1.0^2-b	14428.57	2059.22	2992.55	0.96	Higuchi and Shiobara (1980a,b)
	Dog	597		0.062	1.0^2-b	9629.03	1500.95	2154.28	0.95
	Human	131		0.068	1.0^2-b	1926.47	606.32	779.70	0.86
Nilvadipine	Rat	2852	1.00	0.0117	0.922	243760.68	17589.94	27932.16	0.98	Tokuma et al. (1987, 1988)
	Dog	36		0.008	0.836	4500.00	2818.31	3170.52	0.58	Terakawa et al. (1988)
	Human	107		0.013	0.789	8230.77	2539.97	3277.20	0.87	Niwa et al. (1987); in house data
Diazepam	Rat	103.8	1.00	0.137	1.04	757.66	432.66	496.31	0.64	Diaz-Garcia et al. (1992); Luurila et al. (1996)
	Human	0.7		0.032	1.04	21.88	21.53	21.53	0.03	Navia and Chaturvedi (1996); Sawada et al. (1985);Klotz et al. (1976)
Diltiazem	Rat	300.2	1.00	0.184	0.93	1631.52	536.77	684.98	0.85	Tsui et al. (1994); Etoh et al. (1983)
	Dog	201.6		0.298	1.0^2-b	676.54	209.27	269.91	0.87	Kölle et al. (1983); Levet-Trafit et al. (1996)
	Human	64.2		0.22	1.0	291.82	132.79	159.59	0.76	Lee et al. (1992); Piepho et al. (1982)

↵2-a CL_tot.
↵2-b Assumed value.