Estimation of human CLint, in vitro in hepatic microsomes and their values of scaling factor for the model compounds
| Compounds | CLint, in vitro | Scaling Factor (CLint, in vivo/CLint, in vitro) | ||
|---|---|---|---|---|
| Well Stirred | Parallel-Tube | Dispersion | ||
| ml/min/kg body weight | ||||
| FK1052 | 58.90 | 26.6 | 16.1 | 18.2 |
| FK480 | 74.21 | 4.5 | 4.2 | 4.3 |
| Zolpidem | 29.00 | 5.4 | 4.5 | 4.7 |
| Omeprazole | 98.08 | 5.4 | 3.1 | 3.6 |
| Nicardipine | 1736.34 | 1.1 | 0.3 | 0.4 |
| Nilvadipine | 1712.88 | 4.8 | 1.5 | 1.9 |
| Diazepam | 15.00 | 1.5 | 1.4 | 1.4 |
| Diltiazem | 118.15 | 2.5 | 1.1 | 1.4 |