Methods | n | Average Fold Error (CLint, actual/CLint, predicted) | ||
---|---|---|---|---|
Well Stirred | Parallel-Tube | Dispersion | ||
Without scaling factor | 8 | 4.02 | 3.00 | 3.20 |
With rat scaling factor | 7 | 1.57 | 1.85 | 1.67 |
With dog scaling factor | 6 | 1.68 | 2.00 | 1.88 |
The n values refer to the number of predicted values of CLint, in vivo (CLint, predicted) that were compared with the actual human CLint, in vivo obtained from in vivo pharmacokinetic data (CLint, actual).