Table 4

Accuracy of human CLint, in vivo prediction methods

MethodsnAverage Fold Error (CLint, actual/CLint, predicted)
Well StirredParallel-TubeDispersion
Without scaling factor84.023.003.20
With rat scaling factor71.571.851.67
With dog scaling factor61.682.001.88

The n values refer to the number of predicted values of CLint, in vivo (CLint, predicted) that were compared with the actual human CLint, in vivo obtained from in vivo pharmacokinetic data (CLint, actual).