Table 5

Binding of the model compounds to hepatic microsomes and their effects on predicting human CL_{int, in vivo}

Compounds	Microsomal Protein Concentration	f_{u, microsome}		Human CL_{uint, in vitro}	Human Scaling Factor
Compounds	Microsomal Protein Concentration	Rat	Dog	Human CL_{uint, in vitro}	Human	Well Stirred	Parallel-Tube	Dispersion
	mg/ml				ml/min/kg
FK1052	0.5	0.347	0.334	0.323	182.35	8.6	5.2	5.9
FK480	1.0	0.119	0.120	0.112	662.59	0.5	0.5	0.5
Zolpidem	0.5	0.938	0.940	0.939	30.88	5.1	4.2	4.4
Omeprazole	0.5	0.929	0.972	0.975	100.59	5.3	3.1	3.5
Nicardipine	0.2	0.175	0.183	0.129	13460	0.1	0.05	0.06
Nilvadipine	0.2	0.469	0.470	0.443	3866.55	2.1	0.7	0.8
Diazepam	0.5	0.781	0.752	0.745	20.13	1.1	1.1	1.1
Diltiazem	0.2	N.D.	0.907	0.863	136.91	2.1	1.0	1.2